A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFα

机译：一种有效且选择性的p38抑制剂可保护小鼠胶原蛋白诱发的关节炎中的骨质破坏：与小鼠TNFα的中和比较

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

获取外文期刊封面目录资料

页面导航

摘要
著录项
引文网络
相似文献
相关主题

摘要

Background and purpose:The p38 kinase regulates the release of proinflammatory cytokines including tumour-necrosis factor-α (TNFα) and is regarded as a potential therapeutic target in rheumatoid arthritis (RA). Using the novel p38 inhibitor Org 48762-0, we investigated the therapeutic potential of p38 inhibition and compared this to anti-mouse (m)TNFα antibody treatment in murine collagen-induced arthritis (CIA).

机译：背景与目的：p38激酶调节包括肿瘤坏死因子-α（TNFα）在内的促炎细胞因子的释放，被认为是类风湿关节炎（RA）的潜在治疗靶标。使用新型的p38抑制剂Org 48762-0，我们研究了p38抑制的治疗潜力，并将其与鼠胶原诱导的关节炎（CIA）中的抗小鼠（m）TNFα抗体治疗进行了比较。

著录项

期刊名称 British Journal of Pharmacology and Chemotherapy
作者
K Mihara; C Almansa; R L Smeets; E E M G Loomans; J Dulos; P M F Vink; M Rooseboom; H Kreutzer; F Cavalcanti; A M Boots; R L Nelissen;
展开▼
作者单位

展开▼
年(卷),期 2008(154),1
年度 2008
页码 153–164
总页数 12
原文格式 PDF
正文语种
中图分类药学;
关键词
p38 MAPK Org 48762-0 anti-TNFα therapy collagen-induced arthritis inflammation rheumatoid arthritis proinflammatory cytokines bone damage;

机译：p38 MAPK;Org 48762-0;抗TNFα治疗;胶原蛋白诱发的关节炎;炎症;类风湿性关节炎;促炎细胞因子;骨损伤;

相似文献

外文文献
中文文献
专利

1. Attenuation of Murine Collagen-Induced Arthritis by a Novel,Potent,Selective Small Molecule Inhibitor of kB Kinase 2,TPCalpha-1(2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide),Occurs via Reduction of Proinflammatory Cytokines and [J] . Patricia L.Podolin, James F.Callahan, Brian J.Bolognese, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2005,第1期

机译：一种新型的，有力的，选择性的kB激酶2，TPCalpha-1（2-[（（氨基羰基）氨基] -5-（4-氟苯基）-3-噻吩甲酰胺）选择性强小分子抑制剂对小鼠胶原蛋白关节炎的缓解作用减少促炎细胞因子和
2. Anti-arthritis effect of a novel quinazoline derivative through inhibiting production of TNF-alpha mediated by TNF-alpha converting enzyme in murine collagen-induced arthritis model [J] . Pu Yuzhi, Cao Dong, Xie Caifeng, Biochemical and Biophysical Research Communications . 2015,第4期

机译：一种新型喹唑啉衍生物通过抑制鼠胶原诱导的关节炎模型中TNF-α转化酶介导的TNF-α产生的抗关节炎作用
3. A Selective p38alpha Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis [J] . Satyanarayana Medicherla, Jing Ying Ma, Ruban Mangadu, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2006,第1期

机译：选择性p38alpha丝裂原激活的蛋白激酶抑制剂可逆转胶原蛋白诱发的小鼠的软骨和骨破坏。
4. Loss of SH3BP2 function suppresses bone destruction in TNF-driven and collagen-induced arthritis mouse models [O] . Tomoyuki Mukai, Richard Gallant, Shu Ishida, -1

机译：SH3BP2功能的丧失抑制了TNF驱动和胶原诱导的关节炎小鼠模型中的骨破坏
5. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFα [O] . Mihara, K, Almansa, C, Smeets, R L, 2008

机译：一种有效且选择性的p38抑制剂可保护小鼠胶原蛋白诱发的关节炎中的骨质破坏：与小鼠TNFα的中和比较

A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFα

摘要

著录项

引文网络

相似文献

相关主题

期刊订阅