Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats

机译：长期摄入乙醇可调节麻醉大鼠的内皮素-1受体血管水平并增强对内皮素-1的升压反应

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摘要

Background and purpose:The contribution of endothelin-1 (ET-1) to vascular hyper-reactivity associated with chronic ethanol intake, a major risk factor in several cardiovascular diseases, remains to be investigated.

机译：背景与目的：内皮素-1（ET-1）对与慢性乙醇摄入有关的血管高反应性的贡献，慢性乙醇摄入是几种心血管疾病的主要危险因素，尚待研究。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
C R Tirapelli; E Legros; I Brochu; J-C Honoré; V L Lanchote; S A Uyemura; A M de Oliveira; P DOrléans-Juste;
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作者单位

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年(卷),期 2008(154),5
年度 2008
页码 971–981
总页数 11
原文格式 PDF
正文语种
中图分类药学;
关键词
chronic ethanol consumption blood pressure ET-1 ETA receptors;

机译：慢性乙醇消耗;血压;ET-1;ETA受体;

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专利

1. Enhanced levels of endogenous endothelin-1 contribute to the over expression of Giα protein in vascular smooth muscle cells from SHR: Role of growth factor receptor activation [J] . Gomez Sandoval Y.-H., Anand-Srivastava M.B. Cellular Signalling . 2011,第2期

机译：内源性内皮素-1水平升高导致SHR血管平滑肌细胞中Giα蛋白的过度表达：生长因子受体激活的作用
2. Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia [J] . Francis Y. Kim, Elizabeth A. Barnes, Lihua Ying, American Journal of Physiology . 2015,第2aPta1期

机译：肺动脉平滑肌细胞内皮素-1表达调节慢性缺氧的肺血管反应
3. Bucindolol attenuates the vascular remodeling of pulmonary arteries by modulating the expression of the endothelin-1 A receptor in rats with pulmonary arterial hypertension [J] . de Lima-Seolin Bruna Gazzi, Hennemann Matheus Mittmann, Fernandes Rafael Oliveira, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

机译：BucIndolol通过调节肺动脉高压大鼠内皮素-1 A受体的表达来衰减肺动脉的血管重塑
4. Endothelin-1 Levels in Chronic Congestive Heart Failure [C] . Ohmae M. International Congress on Coronary Artery Disease. . 2013

机译：内皮素-1水平慢性充血性心力衰竭
5. Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells [D] . Mikhail, Marianne 2008

机译：内皮素-1及其受体ETA和ETB在人类血管内皮细胞存活中的作用
6. Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies: Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia [O] . Francis Y. Kim, Elizabeth A. Barnes, Lihua Ying, -1

机译：肺部疾病中的生物标记物：从发病机理到预测到新疗法：肺动脉平滑肌细胞内皮素-1的表达调节对慢性缺氧的肺血管反应
7. Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats [O] . Tirapelli, C R, Legros, E, Brochu, I, 2008

机译：长期摄入乙醇可调节麻醉大鼠的内皮素-1受体血管水平并增强对内皮素-1的升压反应
8. Hemorrhagic Shock-Induced Vascular Hyporeactivity in the Rat: Relationship to Gene Expression of Nitric Oxide Synthase, Endothelin-1, and Select Cytokines in Corresponding Organs. [R] . Liu, L., Dubick, M. A. 2005

机译：出血性休克诱导的大鼠血管低反应性：与相应器官中一氧化氮合酶，内皮素-1和选择细胞因子的基因表达的关系。

Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats

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