Role of InsP3 and ryanodine receptors in the activation of capacitative Ca2+ entry by store depletion or hypoxia in canine pulmonary arterial smooth muscle cells

摘要

Background and purpose:Experiments were performed to determine if capacitative Ca²⁺ entry (CCE) in canine pulmonary arterial smooth muscle cells (PASMCs) is dependent on InsP3 receptors or ryanodine receptors as induction of CCE is dependent on simultaneous depletion of the functionally separate InsP3- and ryanodine-sensitive sarcoplasmic reticulum (SR) Ca²⁺ stores in these cells.