Blockade by burimamide of the restorative effect of histamine in tetrodotoxin-treated heart preparations.

摘要

1 In isolated heart preparations in which fast sodium channels were blocked by tetrodotoxin (2-4 x 10(-5) M), excitability was restored by histamine (6 x 10(-6) M to 10(-5) M). 2 This effect was antagonized by EDTA (2 X 10(-6) M),D600 compound (0.5mug/ml) and the H2-receptor antagonist, burimamide(2 X 10(-4) M).