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Cancer mortality among man-made graphite electrode manufacturing workers: results of a 38 year follow up

机译:人造石墨电极制造工人的癌症死亡率:38年随访结果

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摘要

>Background and Aims: To examine the risk for cancer mortality among workers exposed to coal tar and coal tar pitch volatiles in a man-made graphite electrode factory. The risk for cancer mortality in this type of factory is still inconclusive, although coal tar and coal tar pitch are recognised as human carcinogens. >Methods: The study cohort consisted of 332 male employees who served more than five years in the period 1951–74. The cohort was traced until 1988. Analyses used standardised mortality ratios (SMRs) to compare cause specific mortality with that in the general and local population. Effect of smoking was estimated based on the information collected from the subgroup of the cohort. SMRs for leading causes of death were compared among different job titles, duration of employment, time since first employment, and observation subperiods. Exposure level for tar and benzo[a]pyrene (BaP) in the factory was also discussed, based on measurements done by other researchers in the past. >Results: During the study period, 52 deaths were identified (SMR 0.68), including 22 cancer deaths (SMR 1.01). The SMR for lung cancer was significantly increased in comparison with the general population (SMR 2.62). It was slightly decreased in comparison with the local population, but remained significant (SMR 2.35). Excess deaths were also observed for lymphatic and haematopoietic cancers (SMR 3.46). Smoking habits in the subgroup were similar to those in the general population; thus the increased SMR for lung cancer was unlikely to be explained by smoking. >Conclusion: Previous environmental measurements suggested that considerable exposure to tar and BaP had existed in the factory. The results suggest a possible risk for lung cancer among the cohort, but the limitations of the study, such as the small study population and insufficient information on exposure, indicate that further study is required.
机译:>背景和目标:要检查人造石墨电极工厂中暴露于煤焦油和煤焦油沥青挥发物的工人中癌症死亡的风险。尽管煤焦油和煤焦油被认为是人类致癌物,但在这种类型的工厂中癌症死亡的风险仍然不确定。 >方法:该研究队列由332名男性员工组成,他们在1951-74年期间服务了五年以上。追踪该人群直到1988年。分析使用标准化死亡率(SMR)将病因特异性死亡率与普通人群和当地人群的死亡率进行比较。根据从该人群亚组收集的信息估算吸烟效果。比较了不同职位,工作时间,首次就职时间和观察子期间的主要死亡原因的SMR。根据过去其他研究人员所做的测量,还讨论了工厂中焦油和苯并[a] re(BaP)的暴露水平。 >结果:在研究期间,确定了52例死亡(SMR 0.68),其中22例癌症死亡(SMR 1.01)。与普通人群相比,肺癌的SMR显着增加(SMR 2.62)。与当地人口相比,它略有下降,但仍然很显着(SMR 2.35)。淋巴癌和造血癌也观察到过量死亡(SMR 3.46)。该亚组的吸烟习惯与普通人群相似。因此,肺癌的SMR升高不可能用吸烟来解释。 >结论:先前的环境测量表明,工厂中存在大量的焦油和BaP暴露。结果表明该人群中可能存在肺癌风险,但是该研究的局限性,例如研究人群少和暴露信息不足,表明需要进一步研究。

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