The Effect of Protein Deficiency and Microsomal Enzyme Induction by DDT and Phenobarbitone on the Acute Toxicity of Chloroform and a Pyrrolizidine Alkaloid Retrorsine

摘要

The sensitivity of rats to the lethal and hepatotoxic effects of chloroform and retrorsine is not altered by feeding low protein or protein-free diets.For retrorsine the lethal effect is not altered by injection of dicophane (DDT) to protein-depleted rats.DDT and phenobarbitone increase the lethal and hepatotoxic effects of chloroform in stock or protein-depleted rats. It seems likely that chloroform requires metabolism to exert its toxic effects, but other factors such as liver fat are also determinants of toxicity.