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A phase Ib study of entinostat plus lapatinib with or without trastuzumab in patients with HER2-positive metastatic breast cancer that progressed during trastuzumab treatment

机译：恩替司他加拉帕替尼联合或不联合曲妥珠单抗治疗HER2阳性转移性乳腺癌患者在曲妥珠单抗治疗期间进展的Ib期研究

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摘要

Demographic and clinical characteristics for the full patient cohort and each treatment group: categorical variables

机译：整个患者队列和每个治疗组的人口统计学和临床特征：分类变量

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期刊名称 British Journal of Cancer
作者
Bora Lim; Rashmi K. Murthy; Jangsoon Lee; Summer A. Jackson; Toshiaki Iwase; Darren W. Davis; Jie S. Willey; Jimin Wu; Yu Shen; Debu Tripathy; Ricardo Alvarez; Nuhad K. Ibrahim; Abenaa M. Brewster; Carlos H. Barcenas; Powel H. Brown; Sharon H. Giordano; Stacy L. Moulder; Daniel J. Booser; Jeffrey A. Moscow; Richard Piekarz; Vicente Valero; Naoto T. Ueno;
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作者单位

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年(卷),期 2019(120),12
年度 2019
页码 -1
总页数 8
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Breast cancer; Breast cancer; Drug development;

机译：乳腺癌;乳腺癌;药物开发;

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专利

1. Trastuzumab Emtansine (T-DM1) Plus S-1 in Patients with Trastuzumab-Pretreated HER2-Positive Advanced or Metastatic Breast Cancer: A Phase Ib Study [J] . Kojima Yasuyuki, Yoshie Reiko, Kawamoto Hisanori, Oncology: International Journal of Cancer Research and Treatment . 2019,第6期

机译：Trastuzumab Emtansine（T-DM1）加S-1患者曲妥珠单抗预处理HER2阳性晚期或转移性乳腺癌：IB研究
2. Phase II evaluation of the efficacy and safety of trastuzumab plus pertuzumab therapy in patients with HER2-positive metastatic breast cancer that had progressed during trastuzumab treatment [J] . J.Cortes, K.Gelmon, P.Fumoleau, European Journal of Cancer Supplements . 2008,第7期

机译：曲妥珠单抗联合培妥珠单抗治疗在曲妥珠单抗治疗期间进展的HER2阳性转移性乳腺癌患者中的有效性和安全性的第二阶段评估
3. A randomized phase II trial of trastuzumab plus capecitabine versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and taxanes: WJOG6110B/ELTOP [J] . Takano Toshimi, Tsurutani Junji, Takahashi Masato, The Breast : . 2018,第期

机译：Trastuzumab Plus Capecitabine的随机阶段II试验与先前用曲妥珠猴和紫杉烷治疗的Her2阳性转移性乳腺癌患者患有Her2-阳性转移性乳腺癌的Capecitabine：WJOG6110B / ELTOP
4. Elevated WBP2 Expression in HER2-Positive Breast Cancers Correlates with Sensitivity to Trastuzumab-Based Neo-Adjuvant Therapy: A Retrospective and Multicentric Study [C] . Yoon Pin Lim International Molecular Medicine Tri-Conference. . 2019

机译：HER2阳性乳腺癌中的WBP2表达升高与基于曲妥珠单抗的新辅助治疗的敏感性相关：回顾性和多中心研究
5. A phase Ib study of safety and pharmacokinetics of trastuzumab emtansine and pertuzumab in Japanese patients with HER2-positive metastatic breast cancer [D] . NOGUCHI, Emi 2019

机译：Ib期研究曲妥珠单抗氨丹宁和帕妥珠单抗在日本HER2阳性转移性乳腺癌患者中的安全性和药代动力学
6. Phase 1B/2 study of the HSP90 inhibitor AUY922 plus trastuzumab in metastatic HER2-positive breast cancer patients who have progressed on trastuzumab-based regimen [O] . Anthony Kong, Daniel Rea, Samreen Ahmed, 2016

机译：HSP90抑制剂AUY922加曲妥珠单抗在已接受曲妥珠单抗治疗的转移性HER2阳性乳腺癌患者中的1B / 2期研究
7. Pyrotinib versus trastuzumab emtansine for HER2-positive metastatic breast cancer after previous trastuzumab and lapatinib treatment: a real-world study [O] . Feng Li, Fengrui Xu, Jianbin Li, 2021

机译：Pyrotinib与Hersutuzumab患者为Her2阳性转移性乳腺癌后的曲妥替尼对其进行了胸膜瘤和拉帕替尼治疗：一个真实的研究

A phase Ib study of entinostat plus lapatinib with or without trastuzumab in patients with HER2-positive metastatic breast cancer that progressed during trastuzumab treatment

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