Fourteen long term survivors with orthotopic (recipient heart replaced by donor heart) and nine with heterotopic cardiac transplants (recipient heart retained) had 24 hour ambulatory electrocardiographic monitoring to detect ventricular arrhythmias. Arrhythmia was uncommon in the patients with orthotopic transplants; none of them had more than one extrasystole per hour. In the patients with heterotopic cardiac transplants the recipient's own heart showed significantly more frequent ventricular arrhythmias than the corresponding donor heart: abnormal complexes (mean/24 h) 4583 vs 42.7; extrasystoles 1772 vs 17.8; pairs 121 vs 0.8. There was no relation between the abnormal ventricular activity of the two hearts in the patients with heterotopic transplants on a beat by beat, hourly, or 24 hour basis. There was no consistent diurnal variation in the frequency of the abnormal ventricular beats after cardiac transplantation. The occurrence of ventricular arrhythmia was unrelated to the interval from operation to the study. In long term survivors of cardiac transplantation the denervated heart shows a little ventricular ectopic activity even when compared with normal hearts. In patients with heterotopic transplants ventricular arrhythmias commonly occur in the recipient's own heart; these are probably related to the underlying severity of the original disease.
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机译:十四名原位长期存活者(接受者心脏被供体心脏替代)和九名异位心脏移植长期存活者(接受者心脏保留)进行了24小时动态心电图监测,以检测室性心律失常。原位移植患者心律不齐不常见。他们每个人每小时的收缩压都超过一个。在进行异位心脏移植的患者中,接受者自身的心脏比相应的供者心脏显示出更频繁的心律失常:异常复合物(平均/ 24 h)4583 vs 42.7;收缩期1772 vs 17.8;对121对0.8。逐次,每小时或24小时的异位移植患者的两心室异常活动之间没有关系。心脏移植后异常心室搏动的频率没有一致的昼夜变化。室性心律失常的发生与手术至研究的间隔无关。在心脏移植的长期幸存者中,即使与正常心脏相比,失神经的心脏也表现出一点心室异位活性。在异位移植患者中,心律失常通常发生在接受者自身的心脏中;这些可能与原始疾病的潜在严重程度有关。
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