Original article: Pulmonary retention of primed neutrophils: a novel protective host response which is impaired in the acute respiratory distress syndrome

摘要

RationaleAcute respiratory distress syndrome (ARDS) affects over 200 000 people annually in the USA. Despite causing severe, and often refractory, hypoxaemia, the high mortality and long-term morbidity of ARDS results mainly from extra-pulmonary organ failure; however the mechanism for this organ crosstalk has not been determined.