Monoclonal antibody against EV71 3Dpol inhibits the polymerase activity of RdRp and virus replication

摘要

BackgroundEnterovirus A 71 (EV71) is a neurotropic virus that may lead to acute flaccid paralysis, encephalitis, cardiopulmonary failure or even death. No vaccine and defensive drug controlling EV71 is currently available, novel and efficient antiviral drug or vaccine is therefore urgently needed. 3D^pol (RNA-dependent RNA polymerase (RdRp)) has been an important target for anti-EV71 drug development.