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Steroidal alkaloids and conessine from the medicinal plant Holarrhena antidysenterica restore antibiotic efficacy in a Galleria mellonella model of multidrug-resistant Pseudomonas aeruginosa infection

机译：药用植物Holarrhena antidysenterica的类固醇生物碱和可西丁在具有多重耐药性的铜绿假单胞菌感染的Galleria mellonella模型中恢复抗生素功效

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摘要

BackgroundThis study aimed to evaluate the efficacy of combinations of steroidal alkaloids and conessine from the Thai medicinal plant Holarrhena antidysenterica with antibiotics against Pseudomonas aeruginosa strains possessing different efflux-pump-mediated multidrug-resistant (MDR) phenotypes in a Galleria mellonella infection model.

机译：背景这项研究旨在评估泰国药用植物Holarrhena antidysenterica的甾体生物碱和余生碱与抗生素的结合，以对抗在假单胞菌感染模型中具有不同外排泵介导的耐多药（MDR）表型的铜绿假单胞菌菌株。

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期刊名称 BMC Complementary and Alternative Medicine
作者
Thanyaluck Siriyong; Supayang Piyawan Voravuthikunchai; Peter John Coote;
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作者单位

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年(卷),期 2018(18),-1
年度 2018
页码 285
总页数 10
原文格式 PDF
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关键词
Conessine Efflux pump inhibitor Galleria mellonella Holarrhena antidysenterica Mex efflux systems;

机译：Conessine;外排泵抑制剂;Malleria mellonella;Holarrhena antidysenterica;Mex外排系统;

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1. Steroidal alkaloids and conessine from the medicinal plant Holarrhena antidysenterica restore antibiotic efficacy in a Galleria mellonella model of multidrug-resistant Pseudomonas aeruginosa infection [J] . Thanyaluck Siriyong, Supayang Piyawan Voravuthikunchai, Peter John Coote BMC Complementary and Alternative Medicine . 2018,第1期

机译：药用植物Holarrhena antidysenterica的类固醇生物碱和可西汀在具有多重耐药性的铜绿假单胞菌感染的Galleria mellonella模型中恢复抗生素功效
2. A Galleria mellonella infection model reveals double and triple antibiotic combination therapies with enhanced efficacy versus a multidrug-resistant strain of Pseudomonas aeruginosa [J] . Jessica Krezdorn, Sophie Adams, Peter J. Coote Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland . 2014,第7期

机译：梅勒氏菌感染模型揭示了与铜绿假单胞菌多药耐药菌株相比具有双重功效的双重和三联抗生素联合疗法
3. Enhanced efficacy of putative efflux pump inhibitor/antibiotic combination treatments versus MDR strains of Pseudomonas aeruginosa in a Galleria mellonella in vivo infection model [J] . Adamson Dougal H., Krikstopaityte Vasare, Coote Peter J. The Journal of Antimicrobial Chemotherapy . 2015,第8期

机译：相对于铜绿假单胞菌的MDR菌株在梅隆回廊体内感染模型中推定外排泵抑制剂/抗生素联合治疗的疗效增强
4. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica [O] . Virendra K Dua, Gaurav Verma, Bikram Singh, 2013

机译：从抗草假单胞菌（Holarrhena antidysenterica）的树皮中分离出的甾体生物碱余生碱的抗疟特性
5. A Galleria mellonella infection model reveals double and triple antibiotic combination therapies with enhanced efficacy versus a multi-drug resistant strain of Pseudomonas aeruginosa. [O] . Krezdorn, Jessica, Adams, Sophie, Coote, Peter John 2014

机译：梅勒氏菌感染模型显示出与铜绿假单胞菌的多重耐药菌株相比，双重和三次抗生素联合疗法具有更高的功效。

Steroidal alkaloids and conessine from the medicinal plant Holarrhena antidysenterica restore antibiotic efficacy in a Galleria mellonella model of multidrug-resistant Pseudomonas aeruginosa infection

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