首页> 美国卫生研究院文献>Arthritis Research >DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter

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DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter

机译：DNA甲基化通过骨形态发生蛋白2（BMP-2）诱导的Smads对SOST启动子CpG区结合亲和力的变化来调节骨关节炎软骨细胞中的硬化蛋白（SOST）表达

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IntroductionSclerostin (SOST), a soluble antagonist of Wnt signaling, is expressed in chondrocytes and contributes to chondrocytes’ hypertrophic differentiation; however its role in osteoarthritis (OA) pathogenesis is not well known. Based on our previous findings on the interaction between Wnt/β-catenin pathway and BMP-2 in OA, we aimed to investigate the role of DNA methylation and BMP-2 on SOST’s expression in OA chondrocytes.

机译：简介硬化蛋白（SOST）是Wnt信号的可溶性拮抗剂，在软骨细胞中表达，有助于软骨细胞的肥大分化。然而，其在骨关节炎（OA）发病机理中的作用尚不为人所知。基于我们先前关于OA中Wnt /β-catenin途径与BMP-2之间相互作用的发现，我们旨在研究DNA甲基化和BMP-2对OA软骨细胞SOST表达的影响。

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期刊名称 Arthritis Research
作者
Ioanna Papathanasiou; Fotini Kostopoulou; Konstantinos N. Malizos; Aspasia Tsezou;
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年(卷),期 2015(17),1
年度 2015
页码 160
总页数 10
原文格式 PDF
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中图分类外科学;
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1. DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter [J] . Ioanna Papathanasiou, Fotini Kostopoulou, Konstantinos N. Malizos, Arthritis Research . 2015,第1期

机译：DNA甲基化通过骨形态发生蛋白2（BMP-2）诱导Smads对SOST启动子CpG区结合亲和力的变化来调节骨关节炎软骨细胞中的硬化蛋白（SOST）表达
2. DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter [J] . Ioanna Papathanasiou, Fotini Kostopoulou, Konstantinos N. Malizos, Arthritis research & therapy. . 2015,第Mara期

机译：通过骨形态发生蛋白2（BMP-2）骨质形成蛋白2（BMP-2）对SOST启动子CPG区域的骨质形成蛋白2（BMP-2）诱导变化调节骨抑制性软骨细胞中的硬化素（SOST）表达
3. DNA METHYLATION REGULATES MIR-140 EXPRESSION IN PRIMARY OSTEOARTHRITIC CHONDROCYTES BY ALTERING SMAD-3 BINDING AFFINITY [J] . Papathanasiou I., Mourmoura E., Malizos K., Osteoarthritis and cartilage . 2019,第Suppla1期

机译：DNA甲基化通过改变Smad-3结合亲和力来调节原发性骨关节炎软骨细胞中的miR-140表达
4. CpG Poor Promoter SULT1C2 Regulated by DNA Methylation and is Induced by Cigarette Smoke Condensate in Lung Cell Lines [D] . Johnson, Candace Jeanette-Sukey 2015

机译：CpG不良启动子SULT1C2受DNA甲基化调节，并由香烟烟雾冷凝物诱导肺细胞系
5. Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene [O] . Yanming Cao, Bin Wang, Ding Wang, 2019

机译：骨质疏松性骨折患者硬化蛋白的表达与SOST基因CpG岛中的DNA甲基化有关
6. DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter [O] . Papathanasiou, I., Kostopoulou, F., Malizos, K. N., 2015

机译：DNa甲基化通过骨形态发生蛋白2（Bmp-2）诱导骨关节炎软骨细胞中的硬化蛋白（sOsT）表达，诱导smads与sOsT启动子CpG区结合亲和力的变化

DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter

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