Intraarticular injection of hyaluronan prevents cartilage erosion periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

摘要

IntroductionIntraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however, the mechanism of action is unclear. In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait changes (measured by stride times) in a murine model of OA.