Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment

摘要

IntroductionGlucocorticoids have extensively been used in the treatment of rheumatoid arthritis and other inflammatory diseases. However, their side-effects remain the major limitation in clinical use and an improved therapeutic index is needed.