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Polymorphisms of CYP2C92 CYP2C93 and VKORC1 genes related to time in therapeutic range in patients with atrial fibrillation using warfarin

机译：CYP2C9 * 2CYP2C9 * 3和VKORC1基因多态性与华法林治疗房颤患者治疗时间的相关性

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IntroductionWarfarin continues to be the most widely used anticoagulant in clinical practice around the world for the prevention of thromboembolic events in patients with atrial fibrillation (AF). The evaluation of the quality of anticoagulation control, estimated by time in therapeutic range (TTR), is accepted as a good method to evaluate the quality of anticoagulation. The variability of TTR can be explained by the presence of variants of the CYP2C9 and VKORC1 genes.

机译：引言华法林仍然是全球临床实践中使用最广泛的抗凝剂，用于预防房颤（AF）患者的血栓栓塞事件。通过在治疗范围内的时间（TTR）估算抗凝控制质量的方法被认为是评估抗凝质量的好方法。 TTR的变异性可以通过CYP2C9和VKORC1基因变体的存在来解释。

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期刊名称 The Application of Clinical Genetics
作者
Maria Mariana Barros Melo da Silveira; Leiliandry de Araújo Melo; Filipe Maia Ferreira Gomes; Leonardo José de Cupertino Barreto da Rocha Andrade; Isabela Paulino Serur; Isabelle Cecília de Vasconcellos Piscoya; Raposo Marina Gueiros; Kleyton Palmeira do Ó; Raul Emídio de Lima; Victor Arthur Eulálio Brasileiro; Luydson Richardson Silva Vasconcelos; Dário Celestino Sobral Filho;
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年(卷),期 2019(12),-1
年度 2019
页码 151–159
总页数 9
原文格式 PDF
正文语种
中图分类遗传学;
关键词
atrial fibrillation time in therapeutic range oral anticoagulant genetic polymorphism;

机译：心房颤动;治疗时间;口服抗凝药;遗传多态性;
入库时间 2022-08-17 16:04:48

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专利

1. Polymorphisms of CYP2C9*2 , CYP2C9*3 and VKORC1 genes related to time in therapeutic range in patients with atrial fibrillation using warfarin [J] . Maria Mariana Barros Melo da Silveira, Leiliandry de Araújo Melo, Filipe Maia Ferreira Gomes, The Application of Clinical Genetics . 2019,第4期

机译：CYP2C9 * 2，CYP2C9 * 3和VKORC1基因多态性与华法林治疗房颤患者治疗时间的关系
2. DNA sensors to assess the effect of VKORC1 and CYP2C9 gene polymorphisms on warfarin dose requirement in Chinese patients with atrial fibrillation [J] . Huang Tao-Sheng, Zhang Ling, He Qiong, Australasian physical & engineering sciences in medicine . 2017,第1期

机译：DNA传感器评估VKORC1和CYP2C9基因多态性对中国房颤患者华法林剂量需求的影响
3. Association between polymorphisms of VKORC1 VKORC1 and CYP2C9 CYP2C9 genes with warfarin maintenance dose in a group of warfarin users in Birjand city, Iran [J] . Fereidouni Mohammad, Moossavi Maryam, Kazemi Touba, Journal of cellular biochemistry. . 2019,第6期

机译：VKORC1 VKORC1和CYP2C9 CYP2C9基因多态性与伊朗Birjand City的一组华法林用户中的Warfarin维持剂量的关系
4. BIOCHEMICAL ANALYSIS OF VKORC1 POLYMORPHISMS IN SOME IRANIAN WARFARIN RESISTANT PATIENTS [C] . F. Sadeghian, P. Ghadam, R. Sharifian the European Peptide Symposium . 2007

机译：一些伊朗华法林耐药患者的VKORC1多态性的生化分析
5. Cost-Effectiveness of Current Anticoagulation Care versus Genetic Testing of CYP2C9 and VKORC1 Prior to Long-Term Warfarin Anticoagulation Care: The Implementation of Discrete Event Simulation Model on the Natural History of Venous Thromboembolism. [D] . Teschemaker, Anna R. 2011

机译：当前抗凝治疗的成本效果与长期华法林抗凝治疗之前的CYP2C9和VKORC1遗传检测的关系：基于静脉血栓栓塞自然史的离散事件模拟模型的实现。
6. Phenprocoumon Dose Requirements Dose Stability and Time in Therapeutic Range in Elderly Patients With CYP2C9 and VKORC1 Polymorphisms [O] . Katharina Luise Schneider, Melanie Kunst, Ann-Kristin Leuchs, 2019

机译：CYP2C9和VKORC1多态性的老年患者治疗范围的苯丙糊治疗剂量要求剂量稳定性和时间
7. Uloga genskog polimorfizma CYP2C9 i VKORC1 u individualizaciji terapije varfarinom kod pacijenata sa akutnim moždanim udarom The role of genetic polymorphism of CYP2C9 and VKORC1 in the individualization of warfarin therapy in patients with acute stroke [O] . Šupe Svjetlana 2011

机译：CYp2C9和VKORC1基因多态性在急性脑卒中患者华法林治疗个体化中的作用CYp2C9和VKORC1基因多态性在急性脑卒中患者华法林治疗个体化中的作用

Polymorphisms of CYP2C9*2 CYP2C9*3 and VKORC1 genes related to time in therapeutic range in patients with atrial fibrillation using warfarin

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Polymorphisms of CYP2C92 CYP2C93 and VKORC1 genes related to time in therapeutic range in patients with atrial fibrillation using warfarin