>Purpose: The purpose is to review the issue of retraction in the scientific literature and to examine the policies on retraction of major biomedical journals.>Method: The historical background of this issue was investigated through a literature search. The Instructions to Authors of 122 major biomedical journals were reviewed for evidence of a policy on the retraction of articles. Editors of those journals with no mention of retraction in their Instructions to Authors were contacted by email and/or postal mail.>Results: Sixty-two percent of the journals investigated did not post or report having a policy on issuing retractions. Only twenty-one (18%) did. The remainder did not post any policy and did not respond to inquiries.>Discussion: Including policies in Instructions to Authors relating to the principled conduct of research and publication will improve the ethical environment in which the scientific community works.
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