Crystallographic Textures and Morphologies of SolutionCast Ibuprofen Composite Films at Solid Surfaces

摘要

The preparation of thin composite layers has promising advantages in a variety of applications like transdermal, buccal, or sublingual patches. Within this model study the impact of the matrix material on the film forming properties of ibuprofen–matrix composite films is investigated. As matrix materials polystyrene, methyl cellulose, or hydroxyl-ethyl cellulose were used. The film properties were either varied by the preparation route, i.e., spin coating or drop casting, or via changes in the relative ratio of the ibuprofen and the matrix material. The resulting films were investigated via X-ray diffraction and atomic force microscope experiments. The results show that preferred (100) textures can be induced via spin coating with respect to the glass surface, while the drop casting results in a powder-like behavior. The morphologies of the films are strongly impacted by the ibuprofen amount rather than the preparation method. A comparison of the various matrix materials in terms of their impact on the dissolution properties show a two times faster zero order release from methyl cellulose matrixcompared to a polystyrene matrix. The slowest rate was observed withinthe hydroxyl ethyl cellulose as the active pharmaceutical ingredients(APIs) release is limited by diffusion through a swollen matrix. Theinvestigation reveals that the ibuprofen crystallization and filmformation is only little effected by the selected matrix materialthan that compared to the dissolution. A similar experimental approachusing other matrix materials may therefore allow to find an optimizedcomposite layer useful for a defined application.