2型糖尿病患者外周血白细胞计数与颈动脉内中膜厚度的相关性研究

摘要

To investigate the correlation of peripheral white blood cell count( WBC) with carotid artary intima-media thickness (IMT) of carotid artery in patients with type 2 diabetes.MethodsIMT and WBC were analyzed in 138 patientswith type 2 diabetes (T2DM) and 46 healthy subjects.ResultsAge, duration of diabetes, WBC, high sensitivity C-reactive pro-tein (hs-CRP), body mass index (BMI), HBA1c were markedly higher in type 2 diabetic patients with abnormal IMT than those with normal IMT (all P<0.05). Spearma correlation analysis showed that WBC was positvely correlated to IMT (rs=0.4295,P< 0.01).Elevated WBC count may be an predictive factor for development of macroangiopathy in type 2 diabetic patiens.%目的 探讨2型糖尿病(T2DM)患者外周血白细胞计数(WBC)与颈动脉内中膜厚度(IMT)的相关性.方法 对138例T2DM患者的WBC与IMT的相关性进行比较.结果 IMT异常组的年龄、病程、WBC、hs-CRP、BMI、HbA1c与IMT正常组比较,差异有统计学意义(P＜0.05或0.01);Spearman 相关分析显示,WBC与IMT成正相关关系(P＜0.01).结论 WBC的升高(虽然在正常范围内)对糖尿病大血管并发症是一个重要的预测因子.