生大黄致结肠黑变病豚鼠肠动力评估

摘要

目的：探讨生大黄致结肠黑变病的动物模型结肠动力的评估方法。方法建立生大黄致结肠黑变病豚鼠模型，观察该动物模型排便改变及结肠HE染色变化。结果生大黄致结肠黑变病豚鼠排便减少，结肠黏膜呈棕黑色改变，HE染色可见棕色颗粒物堆积。结论长期口服生大黄水溶液可致豚鼠发生结肠黑变病，并伴有肠道排便功能下降。钡剂标记排出大便为良好的肠动力评估方法之一。%Objective To investigate the intestinal motility changes of melanosis coli induced by Rhubarb. Methods Melanosis coli was induced by rhubarb in guinea pigs. Barium was used to evaluate the bowel move-ment in guinea pigs. Morphological changes of colon mucosa were also observed. Results The numbers of bowel movements was decreased in guinea pigs with melanosis coli. Histological examination showed that colon mucosa was dark and that accumulating brown particles was seen in the mucosa. Conclusion Long-term use of rhubarb can cause melanosis coli in guinea pigs accompanied by bowel movement reduced. Barium can be used to mark the defecate,which is a good way to evaluate bowel movement.