极性反转一锅法制备联芳基七元内酯

摘要

To develop a simple and efficient procedure for the synthesis of biaryl seven-membered lac-tones. The umpolung reaction was promoted by N-heterocyclic carbenes under oxygen, with anhydrous potas-sium carbonate as base and with 18-crown-6 as a phase-transfer catalyst. The practical protocol was found to be compatible with different structurally diverse substrates. This synthesis method has the advantage of op-eration simplicity, one-step reaction, mild condition, relative environment-friendly and moderate to high yields, providing a useful and atom-economic approach to the synthesis of biaryl seven-membered lactones.%以N-杂环卡宾做极性反转催化剂，以无水碳酸钾为碱、18-冠-6为相转移催化剂，给氧条件下一锅法合成了一系列联芳基七元内酯。该方法适用于各种结构类型的底物；相对于传统的联芳基七元内酯合成方法来说，具有操作简单、一步反应、条件温和，对环境相对友好及较高产率等优点，为联芳基七元内酯的合成提供了一种实用并具有原子经济性的途径。