Rosacea is a chronic facial dermatosis with a progressive course, which is characterized by the presence of erythema,papules, pustules, telangiectasias and sebaceous gland hyperplasia. However, the aetiology is still unknown; genetic predisposition, gastrointestinal disorders (Helicobac- ter pylori), infestations with Demodex folliculorum and environmental stimuli are considered to be involved in the inflammatory process.A metabolite of nicotinamide, 1- methylnicotinamide(MNA+ ), has anti- inflammatory properties, and this is the first study to test the effectiveness of this agent in treating rosacea.In total, 34 patients with rosacea were treated with a gel containing 0.25% MNA+ as a chloride salt, twice daily for 4 weeks,after which improvement was observed in 26/34 cases. The improvement was good in 9/34 and moderate in 17/34, but no clinical effect was noted in seven subjects. In only one case was skin irritation given as the reason for treatment withdrawal.These results indicate that MNA+ might be a useful agent for treating rosacea.
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