B-type natriuretic peptide(BNP) and the N-terminus of pro-BNP(NT-pro-BNP) have prognostic value in patients with heart failure and patients with acute coronary syndromes. Little is known about the prognostic value of baseline NT-pro-BNP alone or in combination with C-reactive protein(CRP) for clinical outcome after percutaneous coronary intervention(PCI). Within a single center registry of contemporaneous PCI, we investigated the prognostic value of baseline plasma NT-pro-BNP and CRP concentrations for the prediction of death or nonfatal myocardial infarction(MI) during 12 to 14 months of follow-up. Among 1,172 consecutive patients, the occurrence of death or MI increased significantly with baseline NT-pro-BNP before PCI(first quartile 0 of 294, second quartile 6 of 291[2.1%], third quartile 4 of 294[1.4%], fourth quartile 22 of 293[7.5%)]; p65 years and NT-pro-BNP as independent significant predictors of death/MI(age OR 3.18, 95%CI 1.32 to 7.67, p=0.01; NT-pro-BNP OR 4.57, 95%CI 2.07 to 10.10, p=0.0001). Baseline NT-pro-BNP before PCI provides important, independent prognostic information for the occurrence of death or nonfatal MI during long-term follow-up.
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