Effect of Moxibustion on Cardiac Remodeling and Myocardial Function in Rats with Exercise-Induced Fatigue

摘要

Objective: To explore the effect of moxibustion at Shenque（CV8） on myocardial structure and function in rats with exercise-induced fatigue. Methods: A 12-week treadmill training program was used to establish a rat model of exercise-induced fatigue. Fifty-six male SD rats removed six rats that did not reach the molding condition, Remaining rats were randomly divided into the following five groups: a normal group（n=10） that did not under go the exercise routine and were not treated, a control group（n=10） that did not under go the exercise routine, but received a mild dose of moxibustion at "Shenque"（CV 8） for 15 min, an untreated group（n=10） that received no treatment after exercise, a CV 8 group（n=10） that received a mild dose of moxibustion at "Shenque"（CV 8） for 15 min after exercise, a non-acupoint（tail） group（n=10） that received a mild dose of moxibustion at "non-acupoint" for 15 min after exercise. At one hour after the end of the 12-week training program, the left ventricular diastolic volume（LVDV）, left ventricular systolic volume（LVSV）, peak early diastolic mitral blood flow velocity（E）, and peak late diastolic mitral blood flow velocity（A） were measured,and the E/A ratio were calculated. The serum myoglobin（Mb）, creatine kinase-muscle/brain（CK-MB）, and cardiac troponin-I（cTnI） levels were detected using an automatic biochemical analyzer. Results: When the values obtained before and after treatment were compared within the same groups, the LVDV, LVSV, E, and A were increased（P＜0.05 or P＜0.01）, and the E/A were decreased（P＜0.01） in the untreated group and the tail group. Regarding inter-group comparisons, the LVDV, LVSV, E, and A were increased（P＜0.05 or P＜0.01）, and the E/A were decreased（P＜0.01） in the untreated group and the tail group compared to the normal group and control group. Compared to the untreated group and the tail group, the LVDV, LVSV, E, and A were decreased（P＜0.01） and the E/A were increased（P＜0.01） in the CV 8 group. Compared to the normal