Effects of Chaihu Guizhi Ganjiang Decoction Combined with Standard Triple Therapy on Reducing Serum CagA and Hp-NAP in Patients with H.pylori-Related Gastritis

摘要

OBJECTIVE: To explore the effects of Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy on treating H.pylori-related gastritis. METHODS: Eighty-two patients with H. pylori-related gastritis treated in our hospital from January 2016 to December 2017 were selected according to the random number table method and divided into experimental group and control group, with 41 patients in each group. The control group was treated with standard triple therapy, while the experimental group was additionally treated with modified Chaihu Guizhi Ganjiang Decoction. The venous blood of one elbow was taken before and after treatment. The concentrations of serum CagA and Hp-NAP were detected by enzyme-linked immunosorbent assay (ELISA). The symptoms were evaluated according to the change of symptom scores before and after the intervention. The H.pylori eradication rate was calculated. RESULTS: There was no significant difference in CagA and Hp-NAP concentrations between the 2 groups before intervention (P > 0.05). After intervention, CagA and Hp-NAP concentrations in experimental group were (19.21±6.27) ng/L and (24.37±6.10) ng/L respectively which were lower than (25.81±7.14) ng/L and (32.09±5.73) ng/L of control group. The differences were statistically significant (P < 0.05). The total effective rate of major symptoms in experimental group was 39 cases (95.12％), which was significantly higher than that of the control group (31 cases, 75.61％). There was statistically significant difference between the 2 groups (P < 0.05). The eradication rate of H.pylori was 38 cases (92.68％) in the experimental group, which was significantly higher than 31 cases (75.61％) of the control group. The difference between the 2 groups was statistically significant (P < 0.05). CONCLUSION: Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy can effectively reduce CagA, Hp-NAP of serum level in patients with H.pylori-related gastritis, improve efficacy of symptoms and eradication rate of H.pylori, and is worthy of clinical promotion.