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The role of advanced glycation end products and their mechanism in DN

机译:晚期糖基化终产物的作用及其在DN中的作用

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摘要

Advanced glycation end products(AGEs), which are macromolecular material such as proteins, lipids, and nucleic acids free amino and reducing sugar on the reaction of aldehyde group under the condition of the enzyme, generate the stable compounds. AGEs formation is enhanced in diabetes and is associated with the development of diabetic complications. AGEs, as an important marker of chronic complications of diabetes mellitus, plays an important role in the development and progression of diabetic nephropathy. In the current review, we discuss mechanisms and the role of AGEs in diabetic nephropathy.
机译:先进的糖基化终产物(AGEs)是大分子物质,例如蛋白质,脂质和核酸,在酶的作用下,通过醛基的反应,可以游离氨基和还原糖,从而生成稳定的化合物。糖尿病中AGEs的形成增强,并与糖尿病并发症的发展有关。 AGEs作为糖尿病慢性并发症的重要标志,在糖尿病肾病的发生发展中起着重要作用。在当前的审查中,我们讨论了糖尿病肾病中AGEs的机制和作用。

著录项

  • 来源
    《世界中西医结合杂志(英文)》 |2017年第003期|P.8-11|共4页
  • 作者单位

    Heilongjiang University of Traditional Chinese Medicine;

    The First Affiliated Hospital of Heilongjiang University of Chinese Medicine;

    The First Affiliated Hospital of Anhui University of Chinese Medicine;

    Heilongjiang University of Traditional Chinese Medicine;

    The First Affiliated Hospital of Heilongjiang University of Chinese Medicine;

    The First Affiliated Hospital of Anhui University of Chinese Medicine;

    Heilongjiang University of Traditional Chinese Medicine;

    The First Affiliated Hospital of Heilongjiang University of Chinese Medicine;

    The First Affiliated Hospital of Anhui University of Chinese Medicine;

    Heilongjiang University of Traditional Chinese Medicine;

    The First Affiliated Hospital of Heilongjiang University of Chinese Medicine;

    The First Affiliated Hospital of Anhui University of Chinese Medicine;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 CHI
  • 中图分类 糖尿病性昏迷及其他并发症;
  • 关键词

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