Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma

Jongkonnee; Thanasai; Temduang; Limpaiboon; Patcharee; Jearanaikoon; Banchob; Sripa; Chawalit; Pairojkul; Srisurang; Tantimavanich; Masanao; Miwa

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Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma

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AIM: To evaluate the role of thymidine phosphorylase (TP) in cholangiocarcinoma using small interfering RNA (siRNA). METHODS: A human cholangiocarcinoma-derived cell line KKU-M139, which has a naturally high level of endogenous TP, had TP expression transiently knocked down using siRNA. Cell growth, migration, in vitro angiogenesis, apoptosis, and cytotoxicity were assayed in TP knockdown and wild-type cell lines. RESULTS: TP mRNA and protein expression were decreased by 87.1% ± 0.49% and 72.5% ± 3.2%, resp...

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《世界胃肠病学杂志：英文版》 |2010年第013期|P.|共1页
作者
Jongkonnee; Thanasai; Temduang; Limpaiboon; Patcharee; Jearanaikoon; Banchob; Sripa; Chawalit; Pairojkul; Srisurang; Tantimavanich; Masanao; Miwa;
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作者单位

Department;

of;

Clinical;

Microbiology;

Faculty;

of;

Medical;

Technology;

Mahidol;

University;

Department;

of;

Clinical;

Chemistry;

Centre;

for;

Research;

and;

Development;

of;

Medical;

Diagnostic;

Laboratories;

Faculty;

of;

Associated;

Medical;

Sciences;

Khon;

Kaen;

University;

Department;

of;

Pathology;

Liver;

Fluke;

and;

Cholangiocarcinoma;

Research;

Center;

Faculty;

of;

Medicine;

Nagahama;

Institute;

of;

Bio-Science;

and;

Technology;

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原文格式 PDF
正文语种 CHI
中图分类胆囊、胆道肿瘤 ;
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Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma

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