INTRODUCTION Worldwide,cancer is an important cause of mortality in children aged over 1 year.[1]Numerically,the major cancers include acute lymphoblastic leukemia,CNS tumors and lymphomas.[2-6]Cancer incidence is increasing in children globally as well as in Pakistan but the etiology is poorly understood.[7]There are an estimated 160 000 new cases and 90 000 deaths per year worldwide in children aged under 15 years.[8]The exact incidence in Pakistan is not known as there is no national tumor registry.
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