Central nervous system manifestations due to iatrogenic adrenal insufficiency in a Ewing sarcoma patient

摘要

Dear editor,Several types of tumors affect adolescents.Despite being rare,the Ewing sarcoma fami ly of tumors represents the second most common primary bone malignancy in children and adolescents.Paraneoplastic Cushing syndrome i s a wel l-known condi t ion characterized by an ectopic secretion of ACTH(or CRH),and in turn of cortisol by tumor cells.Paraneoplastic Cushing syndrome is however very rare in Ewing sarcoma,and to our knowledge,it was only described once.