Drug resistance is a very important problem for cancer chemotherapy. The ma-jor type of drug resistance is due to the overexpression of P-glycoproteins (P-170) in cancer cells. P-170 could pump the drug out of the cells, so the drug could not be accumulated enough to kill the cell-s. We had developed the adriamycin resistant cell line S-180R in BABL/c mice. The cells overexpressP-170 stably. Different dosages of moxa cone were used on Guanyuan (CV 4) point of the mice.Stimulation of drug accumulation was found after administration of moxibustion for 30 min and a doseresponse manner was shown below 400 mg of moxa cone, but a little decrease of the stimulation wasobtained when using 600 mg of moxa cone. These results confirmed positive effects of moxibustion onovercoming the drug resistance through stimulation of drug accumulation in the cancer cells.
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