In the mechanisms of acupuncture analgesia,an important aspect often overlooked is the antiinflammatory effect of acupuncture,which is mainly attained through the self-limiting inflammatory response-inflammatory reflex and its regulation of hypothalamic-pituitary-adrenal(HPA) axis and autonomic nerve system (the vagus nerve and the sympathetic postganglionic fiber).The significance of antiinflammatory effect of acupuncture in analgesia is manifested twofold:The first,inflammatory nociceptive pain is a major type of chronic pain.The second,neurogenic inflammation is the mechanism by which certain acupoints or acu-reflex points (ARPs) are formed at the body surface and have short-cut connections to the pathological focus.Selecting ARPs and applying appropriate sensory stimulation or local microtrauma (affected by different needling means or stimulation parameters),combined with low-frequency electrical stimulation or the vagus stimulation in the concha region,are helpful to strengthen the anti-inflammatory and analgesic effect of acupuncture.
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