Aim: Previous studies, using different techniques, have yielded contradictory findings concerning whether bone remodelling is altered in infants of diabetic m others (IDM). The objective of the study was to assess the bone resorption of ID M during the first 3 mo of age. Methods: We conducted a longitudinal study using a specific index of bone resorption, urinary excretion of collagen type I cross -linked N-telopeptide (NTX), to compare bone resorption of a cohort of IDM and that of age-matched controls throughout the first 3 mo of life. Results: NTX/C r ratio in IDM followed the same pattern over time as observed in control infant s, i.e., a rapid increase during the first 10 d of life, a peak at 1 mo of life, and then a progressive decrease at 3 mo of life. There was no statistically sig nificant difference between urinary NTX excretion observed in IDM and that obser ved in controls at any age studied. Conclusion: By using urinary NTX excretion, normal bone resorption was found in IDM throughout the first 3 mo of life.
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