Objective:This study was undertaken to assess the effectiveness of transvaginal ultrasound-guided ovarian interstitial laser-coagulation treatment in anovulatory women with polycystic ovary syndrome (PCOS). Study design:Nineteen anovulatory women with clomiphene citrate-resistant PCOS underwent ultrasound-guided transvaginal ovarian interstitial YAG-laser treatment. In this study,serum hormonal level,spontaneous ovulation rate,and pregnancy rate were assessed. Results:With a spontaneous ovulation rate of 84.2%,16 of 19 cases ovulated regularly during the 6-month postoperative period. The mean serums luteinizing hormone and serum testosterone levels in the second,fourth,and sixth postoperative months were signifi- cantly lower than preoperative levels:5.87 ±2.04 IU/L versus 13.17 ±3.03 IU/L (P < .001) and 2.98 ±1.79 nmol/L versus 5.49 ±3.23 nmol/L (P < .001),respectively. The mean luteinizing hormone/follicle-stimul- ating hormone ratio was also significantly lower postoperatively at 1.09 ±0.30 compared with the preoperative 2.85 ±1.14 (P < .001). There was a cumulative pregnancy rate at 6 months of 32.3%(6/19) among the subjects. No significant operative complications were encountered. Conclusion:The ultrasound-guided transvaginal ovarian interstitial laser treatment may be an effective new method to manage anovulation in PCOS patients.
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