从模型大鼠肺肠功能与组织形态的变化探讨肺与大肠在病理上相互传变的特点

摘要

目的：通过观察“肺病”和“肠病”模型大鼠的肺功能、胃肠功能和肺肠组织形态的同步动态变化，探讨肺与大肠在病理上相互传变的特点。方法：建立“肺病”（慢性支气管炎）和“肠病”（溃疡性结肠炎）两种慢性非特异性炎症动物模型，分别选取三个不同的时间点，同步观察各组模型大鼠的肺功能、胃肠功能、肺组织和结肠组织形态的动态变化情况。结果：“肺病”模型和“肠病”模型的肺功能和胃肠功能（胃内残留率、小肠推进率）在各时间点均出现不同程度的减弱（P＜0.01或P＜0.05）。“肺病”模型和“肠病”模型各时间点的肺组织均不同程度的出现支气管上皮细胞变性、坏死，炎细胞浸润，结肠组织出现灶性上皮细胞变性、坏死，炎细胞浸润。“肺病”模型在肺部病变加重的同时，肠腑病变同步加重，在模型第50天肠腑组织出现显著病变。“肠病”模型在肠部病变加重的同时，肺脏病变同步加重，在第8天肺脏组织出现显著病变。结论：“肺”与“大肠”之间是否发生传变，主要取决于原病脏腑的病理损伤程度。同时，原病脏腑出现病变的时间越长，则传变越明显。%Objective:To discuss the pathological transmission feature between lung and large intestine by observing the synchronous dynamic changes of gastrointestinal and lung function,as well as the pulmonary and intestinal histomorphology of rats with pulmonary dis-ease or enteropathy.Methods:To establish “pulmonary disease(chronic bronchitis)”and “enteropathy (ulcerative colitis)”rats mod-els,then synchronously observe the dynamic changes of the pulmonary function,gastrointestinal function,the lung and colon tissue mor-phology of the models.Results:Besides reduced pulmonary function and inflammatory changes of the lung,the pulmonary disease model rats also suffered from synchronously reduced gastrointestinal function (stomach retention rate,rate of small intestine propulsion)(P<0.01 or P<0.05),as well as degeneration and necrosis of epithelial cell and inflammatory cells infiltration of colon tissue.Besides re-duced gastrointestinal function and inflammatory change of colon tissue,the enteropathy models also suffered synchronously reducing of pulmonary function (P<0.01 or P<0.05)and degeneration,necrosis and inflammatory cells infiltration of bronchial epithelial cell. When the problem in lung of the pulmonary disease model is aggravating,the intestinal problem is synchronously aggravating,and signifi-cant lesions appeared at the 50th day after modeling.When the problem in colon of the enteropathy model is aggravating,the pulmonary problem is synchronously aggravating,and significant lesions appeared at the 8th day after modeling.Conclusion:Whether there is trans-mission between lung and large intestine mainly depends on the pathological damage degree of the original disease.At the same time,the longer the change of the viscera disease lesion,the more obvious of the transmission.