目的:考察自拟固本平喘化痰方对慢性阻塞性肺疾病稳定期的临床疗效.方法:将50例慢性阻塞性肺疾病稳定期患者随机分为治疗组和对照组,每组25例.对照组给予常规西医治疗,治疗组在此基础上加用自拟固本平喘化痰方治疗.比较2组患者临床疗效、急性加重次数、血气指标、血清CRP和降钙素原水平.结果:治疗组患者临床治疗疗效显著优于对照组,且急性加重次数显著低于对照组(χ2=4.5,t=1.843,P<0.05).治疗组患者治疗后CO2分压显著低于对照组、O2分压、FVC、FEV1%和PEF显著高于对照组(t=5.590,t=2.907,t=2.169,t=2.980,t=1.952,P<0.01,P<0.05).治疗组患者治疗后血清CRP和PCT水平显著低于对照组(t=1.952,t=1.747,P<0.05).结论:自拟固本平喘化痰方对慢性阻塞性肺疾病稳定期的治疗具有良好效果,可以有效改善患者临床症状预防急性发作,具有临床应用价值.%Objective: To investigate the clinical effects of Guben Pingchuan Huatan Decoctionon in treating chronic obstructive pulmonary disease .Methods:Patients with chronic obstructive pulmonary disease were randomly divided into treatment group and control group , with 25 patients in each group .The control group was given conventional western medicine treatment , while the treatment group was additionally treated with Guben Pingchuan Huatan Decoction .The clinical efficacy , acute exacerbation , blood gas index , serum CRP and serum PCT level were compared between the two groups .Results: The clinical curative effect of the treatment group was significantly better than that of the control group , and the number of acute exacerbation was significantly lower than that of the control group (χ2 =4.5,t=1.843,P<0.05).After treatment, the pCO2 of the treatment group was significantly lower than that of the control group and pO 2 , FVC, FEV1%and PEF were significantly higher than those in the control group ( t=5.590, t=2.907, t=2.169, t=2.980, t=1.952, P<0.01, P<0.05).The levels of serum CRP and PCT after treatment were significantly lower in the treatment group than those in the control group (t=1.952,t=1.747,P<0.05).Conclusion:The Guben Pingchuan Huatan Decoction has a great effect in treatment of chronic obstructive pulmonary disease in stable period .It can effectively improve the clinical symptoms of patients to prevent acute attacks and is valuable for clinical application .
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