猴头菌提取物颗粒治疗小儿感染后脾虚综合征的疗效及安全性分析

摘要

目的:探讨猴头菌提取物颗粒治疗小儿感染后脾虚综合征的临床疗效及安全性.方法:选取2016年1月至2016年12月河北省石家庄市第一医院收治的小儿感染后脾虚综合征患者106例,根据随机数字法,将其分为对照组(双歧杆菌乳杆菌三联活菌片治疗,48例)和观察组(对照组治疗基础上,给予猴头菌提取物颗粒治疗,58例),比较2组治疗的总体疗效、症状积分改善情况,以及主要症状疗效.结果:与对照组比较,观察组治疗的总有效率明显增高(96.6％ vs 75.0％,x2=10.64,P ＜0.05),差异有统计学意义;治疗前2组患儿症状积分比较,差异没有统计学意义(8.6±0.7 vs8.5 ±0.6分,=0.04,P＞0.05);与治疗前比较,治疗后观察组(0.4±0.1 vs8.6±0.7分,=7.23,P＜0.05)和对照组(4.2±0.6 vs8.5±0.6分,=4.59,P＜0.05)患儿症状积分均明显降低,差异有统计学意义;与对照组比较,观察组治疗后症状积分明显降低(0.4±0.1 vs4.2±0.6分,t=5.11,P＜0.05),差异有统计学意义;2组患儿治疗期间都没有出现血尿大便常规、肝肾功能、心肌酶学、心电图检查的异常变化.结论:猴头菌提取物颗粒能够明显提高小儿感染后脾虚综合征治疗的临床疗效,并具有较高的治疗安全性,值得临床推广.%Objective:To study the clinical efficacy and safety of hericium erinaceus extract granules in the treatment of spleen deficiency syndrome after infection in children.Methods:A total of 106 children patients with spleen deficiency syndrome after infection in Shijiazhuang First Hospital of Hebei Province from Jan 2016 to Dec 2016 were divided into the control group (treatment of live combined Bifidbacterium and Lactobacillus tablets,48 cases) and the observation group (based on control group,treatment of hericium erinaceus extract granules,58 cases) according to the random number method.The total clinical efficacy,improvements of symptom scores,and curative effect on major symptoms during the treatment period in the two groups were compared.Results:Compared with the control group,the total effective rate of treatment was significantly increased in the observation group with statistical difference (96.6％ vs 75.0％,x2 =10.64,P ＜0.05);There were no statistical difference in the symptom scores before treatment in two groups (8.6 ±0.7 vs 8.5 ±0.6,t =0.04,P ＞0.05);The symptom scores after treatment were significantly decreased in the observation group (0.4 ± 0.1 vs 8.6 ± 0.7,t =7.23,P ＜ 0.05) and the control group (4.2 ± 0.6 vs 8.5 ± 0.6,t =4.59,P ＜ 0.05) with statistical difference when compared with that before treatment;Compared with the control group,the symptom scores after treatment were significantly decreased in the observation group with statistical difference (0.4 ± 0.1 vs 4.2 ± 0.6,t =5.11,P ＜ 0.05);There were no abnormal changes in blood routine,urine routine,stool routine,liver and kidney function,myocardial enzyme and electrocardiogram in two groups.Conclusion:The treatment of hericium erinaceus extract granules can significantly increase the clinical efficacy of spleen deficiency syndrome after infection in children with higher treatment safety,and is worthy of clinical promotion.