炎症性肠病(IBD)是病因和发病机制尚不明确的慢性炎症性疾病,包括克罗恩病(CD)和溃疡性结肠炎(UC).针灸在治疗IBD上具有显著的疗效和优势,但其作用机制需深入研究和探讨.近年来研究发现lncRNAs广泛参与机体的生理病理过程,尤其是可通过基因调控介导机体的免疫炎性反应,与包括IBD在内的多种免疫性疾病都有密切关系.IBD发生时有多种差异表达的lncRNAs,其表达和功能的异常可在IBD炎症的发生发展中有重要作用.文章就lncRNA的功能及与IBD关系的研究进展进行了总结,并基于针灸对IBD的治疗作用,以期研究针灸能否通过调控相关lncRNA起到对IBD炎性反应的调节作用,从而为针灸治疗IBD的机制研究提供新的思路.%Inflammatory bowel disease (IBD),including crohn′s disease and ulcerative colitisis,are chronic inflammatory diseases with unclear etiology and pathogenesis.The effect of acupuncture and moxibustion on the treatment of IBD is curative and has significant advantages,but its mechanisms still need to be further studied.Studies in recent years found that lncRNAs widely involved in the physiological and pathological process of the body,especially mediating the immune inflammatory response through gene regulation,and have close relationship with variety autoimmune diseases that including IBD.A variety of lncRNAs differently expressed when IBD occurs,and the abnormal expression and function of lncRNAs play an important role in the development of IBD inflammation.In this article,the functions of lncRNA as well as research progress of its relationship with IBD are summarized,and then base on the treatment of acupuncture and moxibustion on IBD,we in order to study whether acupuncture and moxibustion regulate the inflammatory response of IBD through regulating related lncRNAs,which will provide new ideas for the research on the mechanism of acupuncture and moxibustion on the treatment of IBD.
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