史大卓教授治疗介入后冠心病遣方用药规律的关联性分析

摘要

Objective:To summary the characteristics and principles of prescription and medication of coronary heart disease (CHD) after percutaneous transluminal coronary intervention (PCI) that diagnosed and treated by Professor Shi Dazhuo.Meth-ods:Using the association rule analysis ,the Apriori algorithm implemented by WEKA ( the algorithm proposed by Agrawal re-search) was used to discover the knowledge of association rules of Chinese medicine prescription compatibility .Results:The com-mon compatibility of Chinese herbs used by Professor Shi was as follows :Rhizoma Curcumae with Radix Salviae Miltiorrhizae ,Radix Paeoniae Rubra with Radix Salviae Miltiorrhizae ,Rhizoma Coptidis with Radix Salviae Miltiorrhizae ,Rhizoma Curcumae with Radix Paeoniae Rubra,Rhizoma Ligustici Chuanxiong with Radix Salviae Miltiorrhizae ,Radix Astragali seu Hedysari with Radix Salviae Miltiorrhizae,Rhizoma Curcumae with Rhizoma Ligustici Chuanxiong.Drug groups commonly used were Rhizoma Ligustici Chuanx-iong,Rhizoma Curcumae,Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae; Rhizoma Curcumae,Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae; Rhizoma Ligustici Chuanxiong ,Rhizoma Coptidis,Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae; Rhizo-ma Curcumae,Rhizoma Ligustici Chuanxiong ,Radix Salviae Miltiorrhizae; Rhizoma Curcumae,Rhizoma Ligustici Chuanxiong ,Ra-dix Paeoniae Rubra; Radix Paeoniae Rubra,Radix Astragali seu Hedysari ,Rhizoma Ligustici Chuanxiong ,Radix Salviae Miltiorrhi-zae; Rhizoma Coptidis,Radix Salviae Miltiorrhizae,Radix Paeoniae Rubra; Radix Salviae Miltiorrhizae,Rhizoma Ligustici Chuanx-iong,Radix Salviae Miltiorrhizae; Rhizoma Coptidis,Rhizoma Ligustici Chuanxiong,Radix Salviae Miltiorrhizae and so on.Conclu-sion:Professor Shi commonly used compatibility of Chinese herbs in the treatment of CHD are as follows :Radix Salviae Miltiorrhi-zae,Radix Paeoniae Rubra,Rhizoma Coptidis,Rhizoma Ligustici Chuanxiong ,Radix Astragali seu Hedysari.The results revealed that Professor Shi focused on tonifying qi ,promoting blood circulation ,activating blood circulation and detoxification in the treatment of CHD after PCI.%目的:基于数据挖掘技术分析史大卓教授辨治介入后冠心病的遣方用药特点和规律.方法:利用关联规则分析,采用WEKA实现的Apriori算法(即Agrawal研究提出的算法),进行中药组方配伍的关联规则知识发现.结果:史教授辨治介入后冠心病常用的中药配伍有:莪术配丹参、赤芍配丹参、黄连配丹参、莪术配赤芍、川芎配丹参、生黄芪配丹参、莪术配川芎;常用的多个药物配伍(药组)有:川芎、莪术、赤芍、丹参,莪术、赤芍、丹参,川芎、黄连、赤芍、丹参,莪术、川芎、丹参,莪术、川芎、赤芍,赤芍、生黄芪、川芎、丹参,黄连、丹参、赤芍,赤芍、川芎、丹参,黄连、川芎、丹参等.结论:史教授治疗介入后冠心病常用的重要组方配伍为丹参、赤芍、黄连、川芎、生黄芪,体现了他临床善用益气、活血、解毒的遣方用药特点.