阿托伐他汀联合丹红注射液治疗急性冠脉综合征45例

摘要

Objective:To assess the effects of atorvastatin calcium joined with DanHong injection on four items of blood lipid, inflammatory factor and cardiac function of the patients with acute coronary syndrome (ACS) . Methods:Ninety ACS patients who were enrolled in the prospective inclusion study and preformed PCI were randomized into the observation group and the control group. The control group were given atorvastatin calcium, 10 mg each time, once each day, oral administration; the observation group accepted DanHong injection 20 m L each time, once each day, venous dripping. The changes of cardiac function, inflammatory factor and four ite m s of blood lipid of both groups were compared before and after treating after they were followed for three months. Results: The difference had statistical meaning in the comparisons of the levels of TC, LDL-C, HDL-C, TG, hs-CRP and s CD40 L, ejection fraction (EF) and six-minute walking distance within two groups before and after treating (P＜0.05) ; the difference showed statistical meaning in the comparisons between both groups after treating (P ＜0.05) . Conclusion:Atorvastatin calcium joined with DanHong injection could improve cardiac function of ACS patients who accepted PCI surgery, and the effects might be related to inhibiting the inflammatory factors hs-CRP and s CD40 L.%目的:评价阿托伐他汀和丹红注射液联用对急性冠脉综合征 (ACS) 患者血脂4项、炎症因子和心脏功能的影响.方法:前瞻性纳入行PCI手术治疗的90例ACS患者, 随机分为观察组45例和对照组45例.对照组给予阿托伐他汀钙片10 mg/次, 1次/d, 口服;观察组在此基础上加用丹红注射液20 m L/次, 1次/d, 静脉滴注.随访3个月, 比较2组治疗前后血脂4项、炎症因子和心脏功能的变化情况.结果:总胆固醇 (TC) 、低密度脂蛋白 (LDL-C) 、高密度脂蛋白 (HDL-C) 、甘油三酯 (TG) 及超敏C反应蛋白 (hs-CRP) 、可溶性CD40配体 (s CD40L) 水平、射血分数、6分钟步行距离治疗前后2组组内比较, 差异有统计学意义 (P＜0.05) ;治疗后组间比较差异也有统计学意义 (P＜0.05) .结论:阿托伐他汀联合丹红注射液可改善行PCI手术治疗的ACS患者的心脏功能, 该作用可能与抑制炎症因子hs-CRP, s CD40L有关.