血必净联合醒脑静治疗阿普唑仑中毒的疗效观察

摘要

Objective: To observe clinical effects of XueBiJing and XingNaoJing in treating alprazolam poisoning. Methods: Eighty patients were separated into two groups according to random number table method, 40 cases each group, on the foundation of conventional therapy of Western medicine, the control group accepted intravenous dripping of XingNaoJing injection, 15 m L, 0.9％ physiological saline, 250 mL, once each day; and the observation group intravenous dripping of XueBiJing injection, 50 mL, 0.9％ physiological saline, 100 mL, twice each day, both groups were treated for five consecutive days as one course. Rescue success rate was observed, the changes of MDA, SOD and total antioxidant capacity were observed, and the levels of CRP, IL-6 and TNF-α of the patients were compared between both groups. Results: The levels of CRP, IL-6 and TNF-α of the observation group were lower than these of the control group (P＜0.05); the observation group was higher than the control group in the levels of SOD and total antioxidant capacity (P ＜0.05); rescue success rate of the observation group was 92.5％, higher than 62.5％ of the control group (P ＜0.05). Conclusion: XueBiJing and XingNaoJing could reduce inflammatory reaction of the patients, relieve oxidative stress injury and raise clinical rescue and treatment rates.%目的:观察血必净联合醒脑静治疗阿普唑仑中毒的临床疗效.方法:将阿普唑仑中毒患者80例按照随机数字表法分为2组各40例,2组患者在西医常规治疗的同时对照组使用醒脑静注射液15 m L+0.9％生理盐水250 m L静脉滴注,1次/d;观察组在对照组基础上使用血必净注射液50 m L+0.9％生理盐水100 m L静脉滴注,2次/d,2组均连续治疗5天为1个疗程.比较2组患者肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和C反应蛋白(CRP)水平,观察丙二醛(MDA)、超氧化物歧化酶(SOD)及总抗氧化能力变化情况,并观察抢救成功率.结果:观察组TNF-α、IL-6、CRP及MDA水平低于对照组(P＜0.05),而SOD水平及总抗氧化能力高于对照组(P＜0.05);观察组抢救成功率为92.5％,高于对照组的62.5％(P＜0.05).结论:血必净联合醒脑静能降低阿普唑仑中毒患者机体炎症反应,减轻氧化应激损伤,提高临床救治成功率.