牙缺失基因的研究进展

摘要

先天缺牙属于牙齿发育异常中牙的数目异常,在临床中是较为常见的疾病,不仅影响患者的咀嚼功能,而且影响其发音、容貌和心理健康.目前遗传连锁和分子生物学研究使得部分综合征性和非综合征性牙缺失的基因突变得以定位.尽管作用机制尚未明了,但现已知涉及的重要突变因子有很多,本文就近年来与综合征性和非综合征性牙缺失相关的基因研究作一综述.%Tooth agenesis,belonging to the abnormal tooth development,is a common disease in clinic.The disease not only affects the person's chewing function,but also influences the pronunciation,appearance and mental health.In the past,genetic linkage and molecular biology research have made clear of part of the genetic mutations' sites of the syndromic and non-syndromic tooth agenesis.Although the mechanism was not clear yet,but the important mutations are now known to be involved in many factors.The syndromic and non-syndromic tooth agenesis related gene are reviewed in this paper.