心肾综合征病理生理机制研究进展

摘要

心肾综合征（ cardiorenal syndrome ，CRS）是指患者同时存在心功能不全和肾损害，且两者之间存在复杂相互作用的临床综合征。随着心、肾功能疾病发生率的与日俱增，CRS的发生呈逐年增加趋势，是临床亟待解决的重要课题。深入探讨CRS病理生理机制对防治CRS具有重要的基础理论和临床指导价值。目前认为心肾相互作用是CRS发生的关键，神经内分泌系统包括交感神经系统、肾素-血管紧张素-醛固酮系统以及氧化应激、炎症反应、血流动力学紊乱等病理生理机制广泛参与其中。近来尿毒症毒素在CRS中的作用日益受到重视。本文对上述CRS研究进展进行综述，为深入探讨CRS机制和防治提供帮助。%Cardiorenal syndrome ( CRS) is the clinical syndrome with heart failure and kid-ney damage , there is a complex interaction between them .As the incidence of heart and renal disea-ses are growing , the incidence of CRS is increasing , it is an important and urgent topic in clinlic .To explore the pathophysiological mechanisms of CRS has an important theoretical basis and clinical guidance value for the prevention and treatment of CRS .Now that the cardiorenal interaction is the key of CRS, the pathophysiological mechanisms such as neuroendocrine system includeing the sym -pathetic and renin angiotensin aldosterone system , oxidative stress , inflammatory reaction and hemo-dynamics are involved .Recently the role of uremictoxins in CRS has been getting more and more attention.This article reviews the research progress of CRS ,offers the help for exploring the patho-physiological mechanisms , the prevention and treatment of CRS .