Polysaccharide-based drug delivery system rooted in traditional Chinese medicine unveils a gateway to immunotherapy

摘要

Tumor immunotherapy represents a pivotal scientific advancement,and the traditional Chinese medicine tenet of harmonizing the body’s equilibrium through the‘Yin-Yang(Yin and Yang refer to the two basic properties of things and things that are opposed to each other)balance’aligns conceptually with tumor immunotherapy’s goal of reinstating the immune system’s functionality[1].Current research suggests that incorporating the‘Yin-Yang balance’philosophy to guide traditional Chinese medicine polysaccharides in immune anti-tumor therapy may amplify their effectiveness in treating tumors[2].However,prevailing studies on the anti-tumor immune response of traditional Chinese medicine polysaccharides primarily focus on enhancing immune function,often overlooking a comprehensive exploration of immunosuppressive factors.Concurrently,the intricacies involved in analyzing and deciphering the composition and structure of traditional Chinese medicine polysaccharides have exacerbated the challenges associated with studying their oral absorption metabolism and in vivo mechanisms of action.This article addresses these intricacies by consolidating research on the structure-activity relationship,absorption and metabolism processes,and the molecular mechanisms influencing tumor immunity related to traditional Chinese medicine polysaccharides.Furthermore,it proposes a strategic framework for advancing the regulation of tumor immune responses through traditional Chinese medicine polysaccharides.This comprehensive exploration aims to establish a robust foundation for the development of novel oral Chinese herbal polysaccharide drugs tailored for the field of tumor immunotherapy.