Clinical significance of serum insulin-like growth factor-1 levels in prostatic cancer

摘要

Objective To study the relationship between serum insulin-like growth factor-1 ( IGF -1) levels and prostatic cancer. Methods The levels of IGF-I was measured with immunoradiometric assay (IRMA) in 37 cases of prostatic cancer,35 cases of benign prostatic hyperplasia(BPH) and in 20 healthy subjects as controls. The serum IGF-I levels were compared to the clinical and pathological grading of the prostatic cancer. 8 cases of prostatic cancer after operation have been followed up. Results The mean levels of serum IGF-1 in prostatic cancer (325.6 ± 100.8 ng/ml) were significantly higher than those in BPH(201.6± 53.8 ng/ml) and healthy subjects(179.0 ±57.2 ng/ml) (P 0.01). Whereas there were no statistical difference between BPH and healthy subjects(P0.05). Statistical difference was noted before(315.8±87.0 ng/ml) and after (224.8 ±88.4 ng/ ml) PCa operation(P 0.01), but significant difference among the various stages of PCa has not been observed( P 0.05).Conclusion The levels of serum IGF-I may