Local application of bFGF and sucralfate during continuous tissue expansion

摘要

Objective To investigate the effect of local application of bFGF and sucralfate during continuous tissue expansion (CTE). Methods CTE combined with local administration of bFGF and sucralfate was used in twelve patients with scar and nasal tip defects. Twenty three expanders were placed in the subcutaneous pockets through intralesion short incisions. Continuous expansion began at 1 - 3 days after expander implantation. The histomorphological changes and epidermal cell proliferation were observed. The clinical results were investigated. Results The average inflation time was 8.9 days. The average interval of the two operating was 13.5 days. The average hospitalization was 28.4 days. The average immediate stretch-back rate of the expanded skin was 25. 7%. The clincal results were satisfactory without any complications. Histolcgical examinations showed that the epidermal, granular and spinous layer became thicker. The basal cells increased significantly. The dermis thinned slightly and the collagen