目的 探讨CA125对肝硬化的诊断价值,为临床利用CA125来鉴别肝硬化和健康人提供依据.方法回顾性分析97例肝硬化病人及88例健康人的实验室检查结果,比较肿瘤标志物AFP、CEA、CA125、CA153、CA199在健康人群与肝硬化患者血清中的差异,并利用受试者工作特征曲线比较两组中血清水平有差异的肿瘤标志物鉴别肝硬化的能力.结果 肝硬化组CEA、CA125及CA153均明显高于健康对照组;AFP、CA199的结果差异无统计学意义.CEA、CA125及CA153的曲线下面积分别为0.656、0.936及0.737.结论 CA125是辅助诊断肝硬化的一个良好指标.%Objective To explore the diagnostic value of CA125 in liver cirrhosis, and to provide evidence for clinical use of CA125 to differentiate liver cirrhosis patients from healthy people. Methods The laboratory results of97 patients with liver cirrhosis and 88 healthy persons were retrospectively analyzed. Levels of AFP, CEA, CA125, CA153 and CA199 between healthy people and patients with liver cirrhosis were compared. The diagnostic efficiencies of CEA, CA125 and CA153 were analyzed by using ROC curve. Results Levels of CEA, CA125 and CA153 in cirrhosis group were significantly higher than those in healthy control group, whereas the levels of AFP and CA199 between the two groups were not significantly different. The areas under the curves of CEA, CA125 and CA153 were 0.656, 0.936 and 0.737, respectively. Conclusion CA125 is a valuable index for distinguishing liver cirrhosis from normal condition.
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