A case report of double-protein expression in primary uterine cervical diffuse large B cell lymphoma and a review of the literature

摘要

Primary non-Hodgkin’s lymphoma of the uterine cervix is rarely observed.Here,we report a case of"double-protein"expression in a primary uterine cervical diffuse large B-cell lymphoma that was detected based on cervical biopsies at Sichuan Cancer Hospital in December 2016 in a 53-year-old woman with a 1-month history of postmenopausal vaginal bleeding.She was diagnosed with stage IVA cervical cancer after workup and treated with six cycles of rituximab+cyclophosphamide+epirubicin+vindesine+prednisone.She showed a positive partial response after two cycles;however,response assessment revealed a progressive disease after six cycles.Based on the current condition,a treatment regimen comprising a combination of second-line chemotherapy and radiotherapy was advised for the patient.Unfortunately,she discontinued her treatment because of various factors.We conclude that"double-protein"expression in primary uterine cervical diffuse large B-cell lymphoma is difficult to treat and has a poor prognosis.Therefore,improving the diagnosis and treatment of this disease should be considered.