紫杉醇联合顺铂治疗复发性宫颈癌的临床观察

摘要

Objective:To observe the efficacy and toxicities of paclitaxel plus cisplatin in the treatment of recurrent cervical cancer.Methods:Twenty-three patients with a diagnosis of recurrent cervical cancer were eligible.Three-weekly chemotherapy reqimen consisted of paclitaxel 135-150 mg/m2 infusion for 3 h on day 1.cisplatin 25 mg/m2 infusion on day 1 to 3.All patients received at least two cycles treatment.Results:The response rates was 47.8%,including CR 2 cases(8.7%),PR9 cases(39.1%).The major toxicity included neutropenia,nausea vomiting,arthralgia,myalgia and alopecia.Conclusion:Paclitaxel combined with cisplatin is an effective therapy with acceptable adverse reactions for recurrent cervical cancer.