Correlation between the quantifiable parameters of blood flow pattern derived with dynamic CT in malignant solitary pulmonary nodules and tumor size

摘要

Objective: To evaluate the correlation between the quantifiable parameters of blood flow pattern derived with dy- namic CT in malignant solitary pulmonary nodules and tumor size. Methods: Sixty-eight patients with malignant solitary pulmo- nary nodules (SPNs) (diameter ≤4 cm) underwent multi-location dynamic contrast material-enhanced (nonionic contrast material was administrated via the antecubital vein at a rate of 4mL/s by using an autoinjector, 4×5 mm or 4×2.5 mm scanning mode with stable table were performed). Precontrast and postcontrast attenuation on every scan was recorded. Blood flow (BF), peak, height (PHSPN), ratio of peak height of the SPN to that of the aorta (SPN-to-A ratio) and mean transit time (MTT) were calculat- ed. The correlation between the quantifiable parameters of blood flow pattern derived with dynamic CT in malignant solitary pul- monary nodules and tumor size were assessed by means of linear regression analysis. Results: No significant correlations were found between the tumor size and each of the peak height (PHSPN) (35.79±10.76 Hu), ratio of peak height of the SPN to that of the aorta (SPN-to-A ratio), (14.27%±4.37) and blood flow (BF) (30.18 mL/min/100 g±9.58) (r=0.180, P=0.142>0.05; r=0.205, P=0.093>0.05; r=0.008, P=0.947>0.05). Conclusion: No significant correlations were found between the tumor size and each of the quantifiable parameters of blood flow pattern derived with dynamic CT in malignant solitary pulmonary nodules.