艾司西酞普兰联合团体人际心理治疗对老年抑郁症患者社会功能及生活质量的影响

摘要

Objective To investigate the effect of escitalopram combined with team interpersonal psychotherapy on social function and quality of life for geriatric depression patients. Methods 84 patients who met the diagnostic criteria of International Classification of Diseases,tenth edition(ICD -10)were divided into the study group(42 cases)and the control group(42 cases)by the random number table. Both groups received escitalopram treatment for 12 weeks,and patients in the study group received team interpersonal psychotherapy once a week. Hamilton Depression Scale -17 item(HAMD -17),Social Disability Screening Schedule(SDSS)and Generic Quality of Life Inventory(GQOLI -74)were used before and after treatment for 12 weeks. Results After treatment,the scores of HAMD -17 and SDSS of two groups were lower than before treatment,and the differences were statistically significant(P <0.01). The scores of HAMD -17 and SDSS of the study group were lower than those of the control group,and the differences were statistically significant(P <0.05 or 0.01). The scores of GQOLI -74 of both groups were improved,and the total score and scores of dimensions of social function and psychological function of the GQOLI -74 in the study group were significantly higher than those of the control group(P <0.01). Conclusion Compared with escitalopram treatment alone,escitalopram combined with team interpersonal psychotherapy may be more effective to improve depression symptoms and social function of geriatric depression patients,and to improve their quality of life.%目的：探讨艾司西酞普兰联合团体人际心理治疗对老年抑郁症患者社会功能及生活质量的影响。方法采用随机数字表法将84例符合《国际疾病分类（第10版）》（ICD -10）抑郁发作和复发性抑郁障碍诊断标准的患者分为研究组和对照组各42例，两组均接受艾司西酞普兰治疗，研究组在此基础上接受每周一次的团体人际心理治疗，两组均治疗12周。于治疗前和治疗12周末采用汉密尔顿抑郁量表17项版（HAMD -17）、社会功能缺陷量表（SDSS）和生活质量综合评定问卷（GQOLI -74）进行评定。结果治疗后两组 HAMD -17和 SDSS 评分均较治疗前低，差异均有统计学意义（P 均<0.01）；研究组 HAMD -17和 SDSS 评分均低于对照组，差异均有统计学意义（P <0.05或0.01）；两组 GQOLI -74评分均较治疗前高，差异均有统计学意义（P 均<0.01）；治疗后研究组 GQOLI -74总评分、社会功能和心理功能维度评分均高于对照组，差异均有统计学意义（P 均<0.01）。结论艾司西酞普兰联合团体人际心理治疗较单用艾司西酞普兰可能更有助于改善老年抑郁症患者的抑郁症状和社会功能，提高其生活质量。