目的 研究TNF-α、IL-10和IL-8在急性脑出血并发SIRS及MODS中的作用.方法 按照SIRS诊断标准和MODS病情分期及严重程度评分标准,收集59例AICH诱发SIRS、导致MODS的患者,并将其分为单纯AICH组、AICH诱发SIRS组和AICH诱发SIRS致MODS组.利用CBA流式蛋白分析系统检测59例AICH诱发SIRS、导致MODS的患者血清TNF-α、IL-10和IL-8含量.结果 单纯AICH组、AICH诱发SIRS组和AICH诱发SIRS致MODS组血清TNF-α、IL-10和IL-8水平全部高于正常对照组(P＜0.05)；AICH诱发SIRS和AICH诱发SIRS致MODS组血清TNF-α、IL-10和IL-8水平均显著高于单纯AICH组(P＜0.05).结论 TNF、IL-10和IL-8参与了AICH诱发SIRS致MODS的病理生理过程,在脑出血并发SIRS及MODS中的起重要作用.%Objective To study the role of the TNF-α、IL-10 and IL-8 play in the pathogenesis of acute intracerebral hemorrhage(AICH)leading to system inflammatory response syndrome (SIRS) which cause the multiple organ dysfunction syndrome (MODS). Methods According to the diagnosis standard of SIRS and MODS, 59 patients with acute introcerebral hemorrhage were harvested, and were divided into 3 groups; simple acute intracerebral hemorrhage (AICH) group, acute intracerebral hemorrhage accompanied with SIRS( AICH + SIRS) group and acute intracerebral hemorrhage accompanied with MODS( AICH + SIRS + MODS) group. The concentrations of TNF-α、IL-10 and IL-8 in serum of patients were analyzed by flow cytometry . Results The concentrations of TNF-α、IL-10 and IL-8 were significantly higher in all 3 groups than in normal group(P＜0.05 ). Significant differences between the concentrations of TNF-α、IL-10 and IL-8 in AICH group and those in AICH + SIRS group were noted (P ＜0. 05 ). There was statistically difference in the concentrations of TNF-α、IL-10 and IL-8 between AICH group and AICH + SIRS + MODS group (P ＜ 0. 05 ). Conclusion The TNF JL-10 and IL-8 may play an important role in the pathogenesis of AICH leading to SIRS which cause the MODS.
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